Nitric Acid → 4-Acetamido-3-nitrobenzophenone

HRID 26377

반응식

HRID 26377 반응식
[C:1](OC(=O)C)(=O)C.[N+:8]([O-:11])(O)=[O:9].[NH2:12][C:13](N)=[O:14].[C:16]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(O)(=O)C>[C:13]([NH:12][C:20]1[CH:21]=[CH:22][C:17]([C:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[O:23])=[CH:18][C:19]=1[N+:8]([O-:11])=[O:9])(=[O:14])[CH3:1]

참가 물질

6

반응물 4

HCID 944Nitric AcidHCID 1176UreaHCID 3102BenzophenoneHCID 7918Acetic Anhydride

생성물 1

HCID 5969694-Acetamido-3-nitrobenzophenone수율 62.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

반응 조건

온도
50 °C

실험 절차

Twenty-three grams (0.1 m.) of 4-acetamidonbenzophenone, 50 ml. of acetic anhydride and 20 ml. of acetic acid were stirred together. A solution of 90 percent nitric acid (15 ml.), 10 ml. of acetic acid and 0.2 g. of urea was added dropwise to the benzophenone mixture. The reaction mixture was maintained at a temperature of about 50° C. during the nitration. The mixture was stirred at ambient temperature whereupon the mixture became very thick. The thick slurry was poured over ice and the insoluble product was filtered to yield 17.7 g. (62.5 percent yield) of 4-acetamido-3-nitrobenzophenone.

후처리

  1. additionThe thick slurry was poured over ice
  2. filtrationthe insoluble product was filtered
  3. customto yield 17.7 g

출처 및 근거

ORD 기록
ord-20ce1551141f46029f3fc8dbcb037de1
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150028

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