Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorobenzaldehyde → Methyl 5-acetyl-2,6-dimethyl-4-(4-chlorophenyl)-1,4-dihydropyridine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorobenzaldehyde | HCID 7726 | — |
| 반응물 | Methyl acetoacetate | HCID 7757 | — |
| 반응물 | 4-Amino-3-penten-2-one | HCID 136873 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | Methyl 5-acetyl-2,6-dimethyl-4-(4-chlorophenyl)-1,4-dihydropyridine-3-carboxylate | HCID 15337221 | — |
반응 단계
5.64 g (40 mmol) of 4-chlorobenzaldehyde, 4.0 g (40 mmol) of 4-aminopent-3-en-2-one and 4.6 g (40 mmol) of methyl acetoacetate are heated to reflux for 12 h in 100 ml of isopropanol. The reaction mixture is allowed to cool and is concentrated. 1.85 g of the title compound crystallize from Et2O.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05646166 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-28c0316e636846f197225b123a7a9827 |
| 출처 메모 | uspto-grants-1997_07 |