참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 반응물 | 2-(Methyl(2-hydroxyethyl)amino)benzothiazole | HCID 600899 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 4-[2-(N-Methyl-N-(2-benzothiazolyl)amino)ethoxy]benzaldehyde | HCID 10403243 | — |
반응 단계
A mixture of 4-fluorobenzaldehyde (1.5 g) and 2-[N-methyl-N-(2-benzothiazolyl)amino]ethanol (2.4 g) in dimethyl sulphoxide (50 ml) containing anhydrous potassium carbonate (2 g) was stirred at 100° C. for 24 hours. The mixture was cooled to room temperature and added to water (300 ml). The aqueous solution was extracted with diethyl ether (2×300 ml). The organic extracts were washed with brine (1×300 ml), dried (MgSO4), filtered and evaporated to dryness. The title compound was obtained as a waxy solid following chromatography on silica-gel in 1% methanol in dichloromethane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05646169 |
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| 출처 데이터셋 | uspto-grants-1997_07 |
|---|
| ORD ID | ord-079453f18d4842d7b7a7a332d6900108 |
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| 출처 메모 | uspto-grants-1997_07 |
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