反应详情

温度

100 °C

A mixture of 4-fluorobenzaldehyde (1.5 g) and 2-[N-methyl-N-(2-benzothiazolyl)amino]ethanol (2.4 g) in dimethyl sulphoxide (50 ml) containing anhydrous potassium carbonate (2 g) was stirred at 100° C. for 24 hours. The mixture was cooled to room temperature and added to water (300 ml). The aqueous solution was extracted with diethyl ether (2×300 ml). The organic extracts were washed with brine (1×300 ml), dried (MgSO4), filtered and evaporated to dryness. The title compound was obtained as a waxy solid following chromatography on silica-gel in 1% methanol in dichloromethane.

1. temperatureThe mixture was cooled to room temperature
2. extractionThe aqueous solution was extracted with diethyl ether (2×300 ml)
3. washThe organic extracts were washed with brine (1×300 ml)
4. dry with materialdried (MgSO4)
5. filtrationfiltered
6. customevaporated to dryness