Sodium Cyanide → 4-amino-1-methylpiperidine-4-carbonitrile

HRID 264019

반응식

HRID 264019 반응식
[OH-].[NH4+:2].[Cl-].[NH4+:4].[C-:5]#N.[Na+].[CH3:8][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=O>>[NH2:2][C:12]1([C:5]#[N:4])[CH2:13][CH2:14][N:9]([CH3:8])[CH2:10][CH2:11]1

참가 물질

5

반응물 4

HCID 8929Sodium CyanideHCID 13603N-Methyl-2-piperidoneHCID 14923Ammonium HydroxideHCID 25517Ammonium Chloride

생성물 1

HCID 114349914-amino-1-methylpiperidine-4-carbonitrile

실험 절차

Using the procedure of Stage 1 of Example 1, 8 ml of ammonium hydroxide, 1.58 g of ammonium chloride and 1.23 g of sodium cyanide were reacted and 2.5 ml of 1-methylpiperidone were added. The mixture was stirred for 18 hours at ambient temperature, followed by extraction r3 times with chloroform. The organic phase was washed with salt water and dried to obtain 2.41 g of the expected product (orange-yellow syrup).

후처리

  1. customwere reacted
  2. extractionfollowed by extraction r3 times with chloroform
  3. washThe organic phase was washed with salt water
  4. customdried

출처 및 근거

ORD 기록
ord-dc5971b1cb52476e8660ccef912bd5c0
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646172

연결된 노트

불러오는 중…