Cytidine → 2'-O-Nonylcytidine

HRID 264737

반응식

HRID 264737 반응식
[C@@H:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[O:9][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[C@H:2]1[OH:3].[H-].[Na+].I[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>CN(C=O)C>[CH2:21]([O:3][C@@H:2]1[C@H:4]([OH:5])[C@@H:6]([CH2:7][OH:8])[O:9][C@H:1]1[N:10]1[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]1=[O:12])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]

참가 물질

5

반응물 3

HCID 6175CytidineHCID 202751-IodononaneHCID 24758Sodium hydride

생성물 1

HCID 228683932'-O-Nonylcytidine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Cytidine (10.1 g, 0.0415 mol), sodium hydride (2.0 g, 1.2 eq), iodononane (9.8 ml, 1.2 eq.) in DMF (100 ml) were reacted as per the procedure of Example 71, Step 1 to yield the 2' and 3' isomers as a sticky foam (11.6 g).

출처 및 근거

ORD 기록
ord-fd8a4e3688574aca93fd2a075c567079
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646265

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