Hippuric Acid → Azlactone

반응식

[C:1]([OH:13])(=[O:12])[CH2:2][NH:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.C(OC(=O)C)(=O)C>>[C:6]1([C:4]2[O:13][C:1](=[O:12])[CH2:2][N:3]=2)[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

참가 물질

반응물 2

HCID 464Hippuric Acid

HCID 7918Acetic Anhydride

생성물 1

HCID 65073Azlactone

반응 조건

온도: 90 °C

실험 절차

23.3 gm of hippuric acid and 93.05 gm of acetic anhydride were charged into a 500 ml eggplant-type flask, and heated on an oil bath at a temperature of 90° C. for 10 minutes. Immediately after the mixture became transparent, it was quenched and kept at 1°-2° C. in ice-water.

후처리

customit was quenched
customkept at 1°-2° C. in ice-water

출처 및 근거

ORD 기록: ord-6f79e5d18511406ebb7adf053fcb96c5
출처 데이터셋: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05646291

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