Hydrochloric Acid → 6-chloro-2,2-bis(fluoromethyl)-2H-1-benzopyran-4-carboxylic acid
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9]([CH2:13][F:14])([CH2:11][F:12])[CH:8]=[C:7]([C:15]([O:17]CC)=[O:16])[C:6]=2[CH:20]=1.[OH-].[K+].Cl>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9]([CH2:13][F:14])([CH2:11][F:12])[CH:8]=[C:7]([C:15]([OH:17])=[O:16])[C:6]=2[CH:20]=1참가 물질
5
실험 절차
A mixture of 0.07 g of ethyl 6-chloro-2,2-bis(fluoromethyl)-2H-1-benzopyran-4-carboxylate, 0.05 g of KOH and 3 ml of ethyl alcohol was stirred at room temperature for 1 hour. Ice water and conc. HCl was added to the reaction mixture and precipitated crystals were collected by filtration to obtain 0.05 g of 6-chloro-2,2-bis(fluoromethyl)-2H-1-benzopyran-4-carboxylic acid with a melting point of 151°-152° C.
후처리
- customprecipitated crystals
- filtrationwere collected by filtration
출처 및 근거
- ORD 기록
- ord-4fa8c74421374fc5810f31e8cd97a89a
- 출처 데이터셋
- uspto-grants-1997_07
- 특허 번호
- US05646308
반응 노트
불러오는 중…