Water → 2-(N-[3-chlorobenzyl]isobutyramido)-4-methyloxazole

HRID 26489

반응식

HRID 26489 반응식
[C:1]([NH:6][C:7]1[O:8][CH:9]=[C:10]([CH3:12])[N:11]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3].C(=O)([O-])[O-].[K+].[K+].[Cl:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23]Br.O>CN(C)C=O>[Cl:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][CH:27]=1)[CH2:23][N:6]([C:7]1[O:8][CH:9]=[C:10]([CH3:12])[N:11]=1)[C:1](=[O:5])[CH:2]([CH3:4])[CH3:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 233485622-iso Butyramido-4-methyloxazole

생성물 1

HCID 213236682-(N-[3-chlorobenzyl]isobutyramido)-4-methyloxazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

2-iso Butyramido-4-methyloxazole (11.1 g., 0.066 mol) prepared in a manner similar to that described in Example 20, was dissolved in dry dimethylformamide. Solid potassium carbonate (10.47 g., 0.076 mol) and 3-chlorobenzyl bromide (15.6 g., 0.076 mol) were added and the stirred mixture was heated at 70° C. for 2 hours, cooled and poured into cold water. The solution was extracted with ether and the extract was dried over magnesium sulphate and evaporated. The residue was distilled to give the product, 12.3 g., b.p. 115-120° C./0.08 mm.

후처리

  1. temperaturecooled
  2. extractionThe solution was extracted with ether
  3. dry with materialthe extract was dried over magnesium sulphate
  4. customevaporated
  5. distillationThe residue was distilled
  6. customto give the product, 12.3 g

출처 및 근거

ORD 기록
ord-67daa2cca30b41ff8b2d549f760e35e1
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150143

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