Methyl iodide → 2-Methoxyphenethyl alcohol

HRID 264915

반응식

HRID 264915 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][OH:10].[C:11]([O-])([O-])=O.[Cs+].[Cs+].CI>CC(C)=O>[OH:10][CH2:9][CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[O:1][CH3:11]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 10796Cesium carbonateHCID 822002-(2-Hydroxyethyl)phenol

생성물 1

HCID 819092-Methoxyphenethyl alcohol

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

To a solution of 10 g of 2-(2-hydroxyphenyl)-ethanol in 200 ml of acetone there are added 35.3 g of Cs2CO3 and then a solution of 6.5 ml of methyl iodide in 40 ml of acetone. The reaction mixture is stirred for 50 minutes at room temperature, is filtered and is concentrated by evaporation. The residue is partitioned between diethyl ether and water. The organic phases are combined, dried over magnesium sulfate and concentrated by evaporation, and the residue is purified by means of FC (dichloromethane/diethyl ether=97:3), yielding the title compound: Rf (dichloromethane/diethyl ether=97:3)=0.34; HPLC Rt =9.31 minutes.

후처리

  1. filtrationis filtered
  2. concentrationis concentrated by evaporation
  3. customThe residue is partitioned between diethyl ether and water
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated by evaporation
  6. customthe residue is purified by means of FC (dichloromethane/diethyl ether=97:3)

출처 및 근거

ORD 기록
ord-1df21698c46c4cba86e23de38fb962c5
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646143

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