Sodium Hydroxide → 2-[N-(3-Carboxypropyl)-isobutyramido]-4-methyloxazole

HRID 26493노트

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HRID 26493 반응식
[C:1]([CH2:6][CH2:7][CH2:8][N:9]([C:15]1[O:16][CH:17]=[C:18]([CH3:20])[N:19]=1)[C:10](=[O:14])[CH:11]([CH3:13])[CH3:12])([O:3]CC)=[O:2].[OH-].[Na+]>C(O)C>[C:1]([CH2:6][CH2:7][CH2:8][N:9]([C:15]1[O:16][CH:17]=[C:18]([CH3:20])[N:19]=1)[C:10](=[O:14])[CH:11]([CH3:13])[CH3:12])([OH:3])=[O:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 213236572[N-(3-carbethoxypropyl)-isobutyramido]-4-methyloxazole

생성물 1

HCID 213236712-[N-(3-Carboxypropyl)-isobutyramido]-4-methyloxazole수율 57.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2[N-(3-carbethoxypropyl)-isobutyramido]-4-methyloxazole (9.9 g., 0.035 mol.) prepared in a manner similar to that described in Example 44 was dissolved in ethanol (100 ml.) and N NaOH solution (35 ml.) and the solution was stirred for 20 hours at ambient temperature. The solution was evaporated and the residue was dissolved in water, washed with ether, acidified and extracted with ether. The extract was dried and evaporated and the residue was recrystallised from benzene-- petrol to give the product 5.1 g., m.p. 81°- 82° C.

후처리

  1. customThe solution was evaporated
  2. dissolutionthe residue was dissolved in water
  3. washwashed with ether
  4. extractionextracted with ether
  5. customThe extract was dried
  6. customevaporated
  7. customthe residue was recrystallised from benzene-- petrol

출처 및 근거

ORD 기록
ord-31d1524c6d344960a649fea493767c04
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150143

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