Hydrochloric Acid → Pivaloyloxymethyl 1-[(2'-carboxybiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

HRID 265047노트

반응식

HRID 265047 반응식
C([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([O:28][CH2:29][O:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])=[O:27])=[C:24]([C:37]([OH:40])([CH3:39])[CH3:38])[N:23]=[C:22]2[CH2:41][CH2:42][CH3:43])=[CH:16][CH:15]=1)=[O:7])(C)(C)C.Cl>O1CCOCC1>[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:15]=[CH:16][C:17]([CH2:20][N:21]2[C:25]([C:26]([O:28][CH2:29][O:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])=[O:27])=[C:24]([C:37]([OH:40])([CH3:39])[CH3:38])[N:23]=[C:22]2[CH2:41][CH2:42][CH3:43])=[CH:18][CH:19]=1)([OH:7])=[O:5]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 10579348Pivaloyloxymethyl 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate

생성물 1

HCID 10816196Pivaloyloxymethyl 1-[(2'-carboxybiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate수율 109.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 6.6 g of pivaloyloxymethyl 1-[(2'-t-butoxycarbonylbiphenyl -4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate [prepared as described in step (c) above] and 57 ml of a 4N solution of hydrogen chloride in dioxane was stirred at room temperature for 4 hours. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and the residue was triturated with ethyl acetate to crystallize it, giving 6.52 g of the title compound as the hydrochloride, melting at 170°-173° C.

후처리

  1. concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
  2. customthe residue was triturated with ethyl acetate
  3. customto crystallize it

출처 및 근거

ORD 기록
ord-eefef9afec9d4d9d9973222c364f5ba7
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646171

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