Sodium Hydroxide → 4-(1-Hydroxy-1-methylethyl)-2-(1-methoxyethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid

HRID 265141

반응식

HRID 265141 반응식
[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH:32]([O:34][CH3:35])[CH3:33])[N:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:9]=1[C:10]([O:12]C)=[O:11])([CH3:4])[CH3:3].[OH-].[Na+]>>[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH:32]([O:34][CH3:35])[CH3:33])[N:8]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:9]=1[C:10]([OH:12])=[O:11])([CH3:3])[CH3:4]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 178497993Methyl 4-(1-hydroxy-1-methylethyl)-2-(1-methoxyethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

생성물 1

HCID 1784948214-(1-Hydroxy-1-methylethyl)-2-(1-methoxyethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid

실험 절차

A solution of 331 m9 of methyl 4-(1-hydroxy-1-methylethyl)-2-(1-methoxyethyl)-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 94(b)] in 3 ml of a 1N aqueous solution of sodium hydroxide was stirred at room temperature for 2.5 hours. At the end of this time, insoluble matter was filtered off and 3 ml of 1N aqueous hydrochloric acid was added to the filtrate. The amorphous powder which precipitated was collected by filtration, to give 209 mg of the title compound, melting at 174°-185° C. (with softening).

후처리

  1. filtrationAt the end of this time, insoluble matter was filtered off
  2. addition3 ml of 1N aqueous hydrochloric acid was added to the filtrate
  3. customThe amorphous powder which precipitated
  4. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-c65f3f1f460a40cd9239562600be85c1
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05646171

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