3-methylsulfonyl-11H-s-triazolo[3,4-b][3]benzazapine → 3-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine

HRID 26525

반응식

HRID 26525 반응식
CS([C:4]1[N:13]2[C:7]([CH2:8][C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[CH:11]=[CH:12]2)=[N:6][N:5]=1)=O.CS(C1N2C(CC3C=CC=CC=3C=C2)=NN=1)(=O)=O.[O-:36][CH2:37][CH3:38].[Na+].C(O)C>C(O)C>[CH2:37]([O:36][C:4]1[N:13]2[C:7]([CH2:8][C:9]3[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=3[CH:11]=[CH:12]2)=[N:6][N:5]=1)[CH3:38]

참가 물질

5

반응물 3

HCID 213235253-methylsulfonyl-11H-s-triazolo[3,4-b][3]benzazapineHCID 213235293-methylsulfinyl-11H-s-triazolo[3,4-b][3]benzazepineHCID 23706232Ethanol sodium ethoxide

생성물 1

HCID 213233563-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

By a procedure similar to that described in Example 35, 0.245 g of 3-methylsulfinyl-11H-s-triazolo [3,4-b][3]benzazepine, in lieu of 3-methylsulfonyl-11H-s-triazolo[3,4-b][3]benzazepine, was reacted with 1.2 ml of 1 N-sodium ethoxide/ethanol in 2 ml of ethanol to obtain 3-ethoxy-11H-s-triazolo[3,4-b][3]benzazepine as crystals. Recrystallization from acetone yielded colorless needles, melting point 143°-144° C. The infrared absorption spectrum of this product was identical with that of the compound obtained in Example 35.

출처 및 근거

ORD 기록
ord-66aacf99ccc542b9aff3e8ef366f46b2
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04150139

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