Methylparaben → Methyl 4-(4-bromobutoxy)benzoate
반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5]Br.[OH:7][C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][O:7][C:8]1[CH:9]=[CH:10][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:16][CH:17]=1참가 물질
5
실험 절차
A mixture of 1,4 dibromobutane (50 ml), methyl 4-hydroxy-benzoate (15.2 g, 0.1 mole), potassium carbonate (40 g) in 2-butanone (500 ml) was refluxed for 24 hours. The mixture was filtered, solvent removed and the residue was chromatographed on silica gel eluted with chloroform/petrol and recrystallised from pentane to give methyl 4-(4-bromobutyloxy)benzoate (19.26 g).
후처리
- temperaturewas refluxed for 24 hours
- filtrationThe mixture was filtered
- customsolvent removed
- customthe residue was chromatographed on silica gel
- washeluted with chloroform/petrol
- customrecrystallised from pentane
출처 및 근거
- ORD 기록
- ord-70044cf59d9d4b0d84034916305dc678
- 출처 데이터셋
- uspto-grants-1997_07
- 특허 번호
- US05648373
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