Acetic Anhydride → N-(4-Methyl-3-nitrophenyl)acetamide

HRID 265449

반응식

HRID 265449 반응식
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:14])[CH3:13])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

참가 물질

3

반응물 2

HCID 7918Acetic AnhydrideHCID 83904-Methyl-3-nitroaniline

생성물 1

HCID 73133N-(4-Methyl-3-nitrophenyl)acetamide

실험 절차

A solution of 4-methyl-3-nitroaniline (3.60 g, 23.7 mmol) in acetic anhydride (28 mL) was allowed to stir at room temperature. After 16 h, the reaction mixture was concentrated in vacuo, diluted with ethyl acetate (25 mL), washed with saturated sodium bicarbonate (2×50 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to give 4.20 g (Y: 99%) of the title compound; 1H-NMR (CDCl3): δ 8.10 (d, J=1.7 Hz, 1H), 7.75 (dd, J=8.5, 1.7 Hz, 1H), 7.38 (bs, 1H), 7.29 (d, J=8.5 Hz, 1H), 2.56 (s, 3H), 2.21 (s, 3H); MS (DCI) m/e: 195 (MH+).

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. additiondiluted with ethyl acetate (25 mL)
  3. washwashed with saturated sodium bicarbonate (2×50 mL)
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-77e0db13534d402782006c6f0acf8b8a
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05648385

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