Sodium Acetate → 4-Amino-6-methyl-2,5-dihydro-1,2,4-triazin-3-one
반응식
C([NH:4][N:5]1[CH2:10][C:9]([CH3:11])=[N:8][NH:7][C:6]1=[O:12])(=O)C.C([O-])(=O)C.[Na+]>Cl>[NH2:4][N:5]1[CH2:10][C:9]([CH3:11])=[N:8][NH:7][C:6]1=[O:12]참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 1.7 g of 4-acetylamino-6-methyl-3-oxo-2,3,4,5-tetrahydro-1,2,4-triazine and 10 ml of 2N hydrochloric acid is stirred for 5 hours at 80° C. After cooling, 1.7 g of sodium acetate are added, and the mixture is concentrated by evaporation in vacuo at a bath temperature of 60° C. The residue is taken up in ethanol, and salt precipitates are filtered off. The filtrate is concentrated to a small volume and caused to crystallize. The title compound is obtained in the form of colorless crystals having a melting point of 116°-119° C.
후처리
- temperatureAfter cooling
- concentrationthe mixture is concentrated by evaporation in vacuo at a bath temperature of 60° C
- customsalt precipitates
- filtrationare filtered off
- concentrationThe filtrate is concentrated to a small volume
- customto crystallize
출처 및 근거
- ORD 기록
- ord-6ad58291dfbf495996ddb626da310eb1
- 출처 데이터셋
- uspto-grants-1997_07
- 특허 번호
- US05648487
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