Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium Hydroxide → 4-[3-(Pyridin-4-yl)propyloxy]benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Methyl 4-[3-(4-pyridinyl)propoxy]benzoate | HCID 53832197 | — |
| 용매 | DCM MeOH AcOH | HCID 21877243 | — |
| 생성물 | 4-[3-(Pyridin-4-yl)propyloxy]benzoic acid | HCID 19034145 | — |
반응 단계
A solution of 19-4 (3.2 g, 11.9 mmol), 1N LiOH (25 mL), and THF (50 mL) was stirred overnight at ambient temperature. After 20 h, the solution was washed with EtOAc and then acidified with 10% KHSO4 to give a suspension of white solid. The aqueous portion was extracted with CHCl3 and then the aqueous portion containing the solid was filtered. After drying the solid at 50° C. for 3 h, 19-5 was obtained. Rf 0.47 (silica, 10/1/1 CH2Cl2 /CH3OH/AcOH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05648368 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-d4fc639ea6b44fd5b7b8b593e7e817de |
| 출처 메모 | uspto-grants-1997_07 |