Sodium Hydroxide → 2-(Adamantan-2-yl)acetic acid

HRID 266037노트

반응식

HRID 266037 반응식
[OH-].[Na+].C[O:4][C:5](=[O:17])[CH2:6][CH:7]1[CH:14]2[CH2:15][CH:10]3[CH2:11][CH:12]([CH2:16][CH:8]1[CH2:9]3)[CH2:13]2>CO>[CH:14]12[CH2:15][CH:10]3[CH2:11][CH:12]([CH2:16][CH:8]([CH2:9]3)[CH:7]1[CH2:6][C:5]([OH:17])=[O:4])[CH2:13]2

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 54117306Methyl 2-adamantylacetate

생성물 1

HCID 8709902-(Adamantan-2-yl)acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Aqueous 2.5 N sodium hydroxide solution 433 ml was added to methanol solution 1125 ml of 2-adamantyl acetic acid methyl ester 150 g (0.72 mol) and stirred at room temperature for 6 hours. Reaction mixture was concentrated in vacuo. Aqueous sodium bicarbonate solution was added to the residue and the mixture was washed with ether. Aqueous layer was adjusted to pH 1 by adding 12 N hydrochloric acid, extracted with ethyl acetate and dried with anhydrous sodium sulfate.

후처리

  1. customReaction mixture
  2. concentrationwas concentrated in vacuo
  3. additionAqueous sodium bicarbonate solution was added to the residue
  4. washthe mixture was washed with ether
  5. additionby adding 12 N hydrochloric acid
  6. extractionextracted with ethyl acetate
  7. dry with materialdried with anhydrous sodium sulfate

출처 및 근거

ORD 기록
ord-e83ba4a8905241d5b530a1f2136bebf4
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650406

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