3-Bromoaniline → 4-(3-Bromophenylamino)-3-ethoxycarbonyl-6-trifluoromethylquinoline

HRID 266077

반응식

HRID 266077 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17].[Br:21][C:22]1[CH:23]=[C:24]([CH:26]=[CH:27][CH:28]=1)[NH2:25].[OH-].[Na+]>C(O)C>[Br:21][C:22]1[CH:23]=[C:24]([NH:25][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([C:12]([F:15])([F:14])[F:13])[CH:10]=3)[N:5]=[CH:4][C:3]=2[C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:26]=[CH:27][CH:28]=1

참가 물질

5

반응물 3

HCID 115623-BromoanilineHCID 14798Sodium HydroxideHCID 4322147Ethyl 4-chloro-6-(trifluoromethyl)quinoline-3-carboxylate

생성물 1

HCID 190324814-(3-Bromophenylamino)-3-ethoxycarbonyl-6-trifluoromethylquinoline

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
95 °C

실험 절차

The reaction mixture of 270.0 mg of 4-chloro-3-ethoxycarbonyl-6-trifluoromethylquinoline and 150 mL of 3-bromoaniline in 4 mL ethanol was heated at 95° C. for 4 h. The reaction was then cooled in an ice-water bath and addid with 2 mL of 0.5N sodium hydroxide solution. The solid was filtered, washed with cold ethaol-water (2:1) and dried to provide 278.0 mg of the titled compound.

후처리

  1. temperatureThe reaction was then cooled in an ice-water bath
  2. filtrationThe solid was filtered
  3. washwashed with cold ethaol-water (2:1)
  4. customdried

출처 및 근거

ORD 기록
ord-47f0e2a705654b17855c3ae306d058a5
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650415

연결된 노트

불러오는 중…