Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoyl chloride → 8-Chloro-2-(n-propylbenzoyl)amino-1,2,3,4-tetrahydronaphthalene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 8-chloro-2-(N-n-propylamino)tetralin | HCID 14969229 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 8-Chloro-2-(n-propylbenzoyl)amino-1,2,3,4-tetrahydronaphthalene | HCID 19032662 | 95% |
반응 단계
To a solution of 53g (0.23 mol) 8-chloro-2-(n-propyl)amino-1,2,3,4-tetrahydronaphthalene and 50 ml triethylamine in 500 ml dichloromethane was added dropwise 33 ml (40 g, 0.28 mol) benzoylchloride. After stirring over night at room temperature, 10% sodium carbonate was added and the mixture was shaken and separated. The organic phase was dried (magnesium sulphate), filtered and evaporated yielding 72 g (95%) raw product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05650427 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-cf8aa99e853643b3a98d70a16e3826d6 |
| 출처 메모 | uspto-grants-1997_07 |