3,4-dihydro-2H-pyran → HCID 19032843, 화합물

HRID 266270

반응식

HRID 266270 반응식
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.[NH2:7][C:8]1[CH:9]=[C:10]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH:11]=[CH:12][CH:13]=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([S:26]([NH:29][CH:30]([CH2:34][OH:35])[C:31](O)=[O:32])(=[O:28])=[O:27])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([S:26]([NH:29][CH:30]([CH2:34][O:35][CH:6]2[CH2:5][CH2:4][CH2:3][CH2:2][O:1]2)[C:31]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][C:15]([O:17][CH3:18])=[O:16])[CH:9]=2)=[O:32])(=[O:27])=[O:28])=[CH:24][CH:25]=1

참가 물질

4

반응물 3

HCID 80803,4-dihydro-2H-pyranHCID 42291702-(4-Chlorobenzenesulfonamido)-3-hydroxypropanoic acidHCID 13054266Methyl 3-aminophenylacetate

생성물 1

HCID 19032843HCID 19032843, 화합물

실험 절차

The procedure described in Example 1 was repeated, except that dihydropyran (0.4 ml) and methyl m-aminophenylacetate (604 mg) were successively reacted with (RS)-2-(4-chlorobenzenesulfonylamino)-3-hydroxypropanoic acid (893 mg) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(3-(methoxycarbonylmethyl)phenyl)-3-(tetrahydropyran-2-yloxy)propanamide (624 mg).

출처 및 근거

ORD 기록
ord-f84d84434c3f469d88f59693f6b2d043
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650428

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