3,4-dihydro-2H-pyran → HCID 19032980, 화합물

HRID 266271

반응식

HRID 266271 반응식
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.Cl.[NH2:8][CH2:9][CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:26][CH:27]([CH2:31][OH:32])[C:28](O)=[O:29])(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([S:23]([NH:26][CH:27]([CH2:31][O:32][CH:6]2[CH2:5][CH2:4][CH2:3][CH2:2][O:1]2)[C:28]([NH:8][CH2:9][CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[O:29])(=[O:24])=[O:25])=[CH:21][CH:22]=1

참가 물질

4

반응물 3

HCID 80803,4-dihydro-2H-pyranHCID 27563834-Aminobutyric acid methyl ester hydrochlorideHCID 42291702-(4-Chlorobenzenesulfonamido)-3-hydroxypropanoic acid

생성물 1

HCID 19032980HCID 19032980, 화합물

실험 절차

The procedure described in Example 1 was repeated, except that dihydropyran (1.37 ml) and methyl 4-aminobutanate hydrochloride (1.69 g) were successively reacted with (RS)-2-(4-chlorobenzenesulfonylamino)-3-hydroxypropanoic acid (2.80 g) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(3-methoxycarbonylpropyl)-3-(tetrahydropyran-2-yloxy)propanamide (3.12 g).

출처 및 근거

ORD 기록
ord-676d72dcd94740218f1078993540da1c
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650428

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