3,4-dihydro-2H-pyran → (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-methoxycarbonylbutyl)-3-(tetrahydropyran-2-yloxy)propanamide

HRID 266272

반응식

HRID 266272 반응식
[O:1]1[CH:6]=[CH:5][CH2:4][CH2:3][CH2:2]1.Cl.[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([NH:27][CH:28]([CH2:32][OH:33])[C:29](O)=[O:30])(=[O:26])=[O:25])=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:19]=[CH:20][C:21]([S:24]([NH:27][CH:28]([CH2:32][O:33][CH:6]2[CH2:5][CH2:4][CH2:3][CH2:2][O:1]2)[C:29]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:16])=[O:14])=[O:30])(=[O:25])=[O:26])=[CH:22][CH:23]=1

참가 물질

4

반응물 3

HCID 80803,4-dihydro-2H-pyranHCID 42291702-(4-Chlorobenzenesulfonamido)-3-hydroxypropanoic acidHCID 13672034Methyl 5-aminopentanoate hydrochloride

생성물 1

HCID 19032845(RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-methoxycarbonylbutyl)-3-(tetrahydropyran-2-yloxy)propanamide

실험 절차

The procedure described in Example 1 was repeated, except that dihydropyran (2.9 ml) and methyl 5-aminopentanate hydrochloride (2.158 g) were successively reacted with (RS)-2-(4-chlorobenzenesulfonylamino)-3-hydroxypropanoic acid (3 g) to obtain (RS)-2-(4-chlorobenzenesulfonylamino)-N-(4-methoxycarbonylbutyl)-3-(tetrahydropyran-2-yloxy)propanamide (2.059 g).

출처 및 근거

ORD 기록
ord-30447eeba407456a81c808bac96e9da9
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650428

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