Sodium Hydroxide → HCID 67706874, 화합물

HRID 266284노트

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HRID 266284 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@@H:12]([CH2:27][O:28][CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][O:30]2)[C:13]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([O:24]CC)=[O:23])=[CH:18][CH:17]=2)=[O:14])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[C:22]([C:19]1[CH:20]=[CH:21][C:16]([NH:15][C:13](=[O:14])[C@@H:12]([NH:11][S:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)(=[O:10])=[O:9])[CH2:27][O:28][CH:29]2[CH2:34][CH2:33][CH2:32][CH2:31][O:30]2)=[CH:17][CH:18]=1)([OH:24])=[O:23]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 67706751HCID 67706751, 화합물

생성물 1

HCID 67706874HCID 67706874, 화합물수율 77.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of (S)-2-(4-chlorobenzenesulfonylamino)-N-(4-ethoxycarbonylphenyl)-3-(tetrahydropyran-2-yloxy)propanamide (200 mg), ethanol (5 ml), and 2N NaOH (2 ml) was stirred at room temperature overnight under argon. The reaction mixture was concentrated under reduced pressure. It was repeated 3 times in order to remove ethanol completely that a small amount of purified water was added to the residue, and the whole was concentrated under reduced pressure. The residue was acidified with 1N HCl, and then extracted with ethyl acetate. The combined ethyl acetate layers were washed with saturated saline solution and dried over Na2SO4. The solvent was evaporated under reduced pressure to obtain (S)-N-(4-carboxyphenyl)-2-(4-chlorobenzenesulfonylamino)-3-(tetrahydropyran-2-yloxy)propanamide (147 mg).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customto remove ethanol completely that a small amount of purified water
  3. additionwas added to the residue
  4. concentrationthe whole was concentrated under reduced pressure
  5. extractionextracted with ethyl acetate
  6. washThe combined ethyl acetate layers were washed with saturated saline solution
  7. dry with materialdried over Na2SO4
  8. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-2a6b807fe1bc4285a55fedd9ffec4529
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05650428

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