Sodium Hydroxide → 2-(Dimethoxyphosphoryl)acetic acid

HRID 26654

반응식

HRID 26654 반응식
C[O:2][C:3](=[O:11])[CH2:4][P:5]([O:9][CH3:10])([O:7][CH3:8])=[O:6].[OH-].[Na+]>>[CH3:8][O:7][P:5]([CH2:4][C:3]([OH:11])=[O:2])([O:9][CH3:10])=[O:6]

참가 물질

3

반응물 2

HCID 14798Sodium HydroxideHCID 80029Trimethyl phosphonoacetate

생성물 1

HCID 1899642-(Dimethoxyphosphoryl)acetic acid

실험 절차

Methyl(dimethoxyphosphinyl)acetate (18.2 g., 0.1 mole) and 1 N sodium hydroxide (100 ml., 0.1 mole) are combined and stirred at room temperature overnight. The reaction mixture is poured onto AG50W-X2 cation exchange resin (200 ml.) and eluted with double distilled water. The acidic fractions are combined and concentrated in vacuo. The residue is dissolved in dichloromethane, dried over magnesium sulfate and concentrated in vacuo to yield 16.8 g. of product, (dimethoxyphosphinyl)acetic acid, yield quantitative.

후처리

  1. additionThe reaction mixture is poured onto AG50W-X2 cation exchange resin (200 ml.)
  2. washeluted
  3. distillationwith double distilled water
  4. concentrationconcentrated in vacuo
  5. dissolutionThe residue is dissolved in dichloromethane
  6. dry with materialdried over magnesium sulfate
  7. concentrationconcentrated in vacuo
  8. customto yield 16.8 g

출처 및 근거

ORD 기록
ord-2672bbd3dffc45ccad4d00207786c751
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151172

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