Methanol → Propanoicacid, 3-phosphono-, 1-methyl ester

반응식

[P:1]([CH:5]([CH3:9])[C:6]([OH:8])=[O:7])([OH:4])([OH:3])=[O:2].[CH3:10]O>>[P:1]([CH:5]([CH3:9])[C:6]([O:8][CH3:10])=[O:7])([OH:4])([OH:3])=[O:2]

참가 물질

반응물 2

HCID 887Methanol

HCID 731872-Phosphonopropionic acid

생성물 1

HCID 18623049Propanoicacid, 3-phosphono-, 1-methyl ester

실험 절차

A solution of 2-phosphonopropionic acid (11.2 g., 0.073 moles) in methanol (150 ml.) is heated at reflux for eighteen hours. The methanol is removed in vacuo. Electrophoresis (0.1 N NH4HCO3, 2000 V, 20 minutes, 7.5 cm) indicates complete conversion to the desired product, methyl 2-phosphonopropionate; yield quantitative.

후처리

temperatureat reflux for eighteen hours
customThe methanol is removed in vacuo
customElectrophoresis (0.1 N NH4HCO3, 2000 V, 20 minutes, 7.5 cm)
customyield quantitative

출처 및 근거

ORD 기록: ord-08ed6c28926644e49ea3dd1c4b37bece
출처 데이터셋: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04151172

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