Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → N-phenyl beta-(8-hydroxy-5-quinolyl)-alpha-cyanoacrylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Acetamide, 2-cyano-N-phenyl- | HCID 69296 | — |
| 반응물 | 8-Hydroxyquinoline-5-carbaldehyde | HCID 275363 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-phenyl beta-(8-hydroxy-5-quinolyl)-alpha-cyanoacrylamide | HCID 54517088 | 75% |
반응 단계
A solution of 8-hydroxy-5-quinolinecarboxaldehyde (1.732 g, 0.010 mol), N-phenyl cyanoacetamide (1.602 g, 0.010 mol) and piperidine (0.255 g, 0.003 mol) in absolute ethanol (50 ml) was heated for 3 h at reflux. The reaction mixture was chilled to about 10°-15° C., the precipitate filtered, the residue washed with ice-cooled ethanol and dried under vacuum. Almost pure title compound was obtained in about 75% yield (2.365 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05652250 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-ca1bb5d3581b40c3be74bfd295d6c6c7 |
| 출처 메모 | uspto-grants-1997_07 |