Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropyl Ether → N-(beta-ethoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | N-Phenyl-1-(phenylmethyl)-4-piperidinamine | HCID 70865 | — |
| 반응물 | 3-Ethoxy-2-propenoyl chloride | HCID 3014429 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | N-(beta-ethoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline | HCID 54194521 | 89.3% |
반응 단계
To a mixture of N-(1-benzyl-4-piperidinyl)aniline (0.9 g), diisopropyl ether (30 ml) and triethylamine (0.5 g) is added β-ethoxyacrylic acid chloride (0.7 g) in portions at 60° C. After refluxing for 1 hour, the reaction mixture is poured into ice-water and extracted with ethyl acetate. The extract is dried and concentrated and to the resulting residue is added n-hexane and the formed crystals are separated by filtration and recrystallized from n-hexane to give N-(β-ethoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline (1.1 g) as white powders, m.p. 106°-108° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05652247 |
| 출처 데이터셋 | uspto-grants-1997_07 |
| ORD ID | ord-74d6a48fc34d420ea124ea78ca355e48 |
| 출처 메모 | uspto-grants-1997_07 |