反应详情

To a mixture of N-(1-benzyl-4-piperidinyl)aniline (0.9 g), diisopropyl ether (30 ml) and triethylamine (0.5 g) is added β-ethoxyacrylic acid chloride (0.7 g) in portions at 60° C. After refluxing for 1 hour, the reaction mixture is poured into ice-water and extracted with ethyl acetate. The extract is dried and concentrated and to the resulting residue is added n-hexane and the formed crystals are separated by filtration and recrystallized from n-hexane to give N-(β-ethoxyacryloyl)-N-(1-benzyl-4-piperidinyl)aniline (1.1 g) as white powders, m.p. 106°-108° C.

1. temperatureAfter refluxing for 1 hour
2. extractionextracted with ethyl acetate
3. customThe extract is dried
4. concentrationconcentrated and to the resulting residue
5. additionis added n-hexane
6. customthe formed crystals are separated by filtration
7. customrecrystallized from n-hexane