Ethanol → Dimaprit hydrochloride
반응식
[ClH:1].[Cl:2][CH2:3][CH2:4][CH2:5][N:6]([CH3:8])[CH3:7].[NH2:9][C:10]([NH2:12])=[S:11].C(O)C>C(OCC)(=O)C>[ClH:2].[ClH:1].[CH3:7][N:6]([CH3:8])[CH2:5][CH2:4][CH2:3][S:11][C:10](=[NH:9])[NH2:12]참가 물질
5
실험 절차
A mixture of 1-chloro-3-(dimethylamino)propane hydrochloride (200 g), thiourea (98.1 g) and ethanol (11) was stirred and heated under reflux for 25 hours. The solution was cooled to ambient temperature and ethyl acetate added until permanent opalescence was obtained. The mixture was stored at 4° C. overnight then filtered to give S-[3-(dimethylamino)propyl]isothiourea dihydrochloride as a colourless solid. (283 g), m.p. 155°-159° C.
후처리
- temperatureheated
- temperatureunder reflux for 25 hours
- customwas obtained
- filtrationthen filtered
출처 및 근거
- ORD 기록
- ord-46b82e97efc7465abd875062f6e51b31
- 출처 데이터셋
- uspto-grants-1997_07
- 특허 번호
- US05652271
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