Chloroacetyl chloride → 4-Chloroacetamido-3-hydroxypyridine

HRID 266915

반응식

HRID 266915 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[OH:8].[Cl:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:9][CH2:10][C:11]([NH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[OH:8])=[O:12]

참가 물질

3

반응물 2

HCID 6577Chloroacetyl chlorideHCID 27624194-Amino-3-hydroxypyridine

생성물 1

HCID 190316634-Chloroacetamido-3-hydroxypyridine

실험 절차

A solution of 4-amino-3-hydroxypyridine (7 g, 0.06 mol) and chloroacetyl chloride (50 ml) was refluxed for 2 hours, cooled and the excess solvent was removed by vacuum distillation. The crude material was dissolved in water, neutralized with Na2CO3 and the solid precipitated filtered and air dried to give the desired product, m.p. 155°-158° C. The structural assignment was supported by the proton NMR spectrum.

후처리

  1. temperaturecooled
  2. customthe excess solvent was removed by vacuum distillation
  3. dissolutionThe crude material was dissolved in water
  4. customthe solid precipitated
  5. filtrationfiltered
  6. customair dried

출처 및 근거

ORD 기록
ord-0e717692545847bf99de662dd998060e
출처 데이터셋
uspto-grants-1997_07
특허 번호
US05652363

연결된 노트

불러오는 중…