Propargyl bromide → 7-(2-Propyn-1-yloxy)-2H-1-benzopyran-2-one

HRID 26695

반응식

HRID 26695 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1.[CH2:13](Br)[C:14]#[CH:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:15]([O:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8](=[O:12])[O:9]2)=[CH:4][CH:3]=1)[C:14]#[CH:13]

참가 물질

5

반응물 3

HCID 7842Propargyl bromideHCID 11430Potassium CarbonateHCID 5281426Umbelliferone

생성물 1

HCID 30511017-(2-Propyn-1-yloxy)-2H-1-benzopyran-2-one수율 60%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 100 ml DMF at 70° C. for 12 hours, 0.1 mole 7-hydroxy-coumarin is reacted with 0.1 mole propargyl bromide in the presence of 0.1 mole potassium carbonate. The compound of the title is obtained at a 60% yield. This compound melts at 118° C.

후처리

  1. customThe compound of the title is obtained at a 60% yield

출처 및 근거

ORD 기록
ord-65bf7f0d4bdc4cc0983572099323cd68
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151291

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