Formic Acid → 5-Nitrobenzimidazole

HRID 26704

반응식

HRID 26704 반응식
[CH:1](O)=O.[N+:4]([C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9]([NH2:14])[CH:8]=1)([O-:6])=[O:5].[OH-].[NH4+]>Cl>[CH:12]1[C:7]([N+:4]([O-:6])=[O:5])=[CH:8][C:9]2[NH:14][CH:1]=[N:13][C:10]=2[CH:11]=1

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 14923Ammonium HydroxideHCID 51117914-Nitro-1,2-phenylenediamine

생성물 1

HCID 71955-Nitrobenzimidazole수율 89%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
80 °C

실험 절차

15 ml of formic acid were added to a suspension of 15.3 g of 4-nitro-1,2-phenylenediamine in 150 ml of 10% hydrochloric acid and the mixture was stirred on a water bath at 80° C. for 3 hours and was cooled. The mixture was made alkaline with concentrated ammonium hydroxide solution and the mixture was filtered. The yellowish needles were washed with water and dried over P2O5 under reduced pressure to obtain 14.3 g (89% yield) of 5(6)-nitro-benzimidazole melting at 209°-211° C.

후처리

  1. temperaturewas cooled
  2. filtrationthe mixture was filtered
  3. washThe yellowish needles were washed with water
  4. dry with materialdried over P2O5 under reduced pressure

출처 및 근거

ORD 기록
ord-ad13d81e56da485d8fb7cb2484db1443
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151280

연결된 노트

불러오는 중…