6-Nitro-3-phenylacetamidobenzoic acid → 6-Aminopenicillanic acid

HRID 267182

반응식

HRID 267182 반응식
C1C=CC(CC(NC2C=CC([N+]([O-])=O)=C(C(O)=O)C=2)=O)=CC=1.[CH3:23][C:24]1([CH3:45])[S:28][C@@H:27]2[C@H:29]([NH:32]C(CC3C=CC=CC=3)=O)[C:30](=[O:31])[N:26]2[C@H:25]1[C:42]([O-:44])=[O:43].[K+]>O>[CH3:23][C:24]1([CH3:45])[S:28][C@@H:27]2[C@H:29]([NH2:32])[C:30](=[O:31])[N:26]2[C@H:25]1[C:42]([OH:44])=[O:43]

참가 물질

4

반응물 2

HCID 1938646-Nitro-3-phenylacetamidobenzoic acidHCID 23664709Penicillin G Potassium

생성물 1

HCID 110826-Aminopenicillanic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
38 °C

실험 절차

330 g of carrier-bound penicillinacylase produced according to Example 1, having an enzymatic activity of 3,410 U (NIPAB test) and 129 g of potassium penicillin G are successively added to 2,000 ml of water and stirred at 38°C. and pH 7.8 as described in Example 14. The penicillin G is completely split to 6-APA and phenylacetic acid over the course of 2 hours. The 6-APA is isolated as described in Example 14. The carrierbound penicillinacylase is employed 20 times in succession. Even after the twentieth splitting, the reaction time does not have to be extended to achieve complete splitting.

후처리

  1. custom330 g of carrier-bound penicillinacylase produced
  2. customThe penicillin G is completely split to 6-APA and phenylacetic acid over the course of 2 hours

출처 및 근거

ORD 기록
ord-4b6ddb4097a74bda95fdc984c65e90cf
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03941756

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