기본 정보
- 표준 SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]- InChIKey
IYNDLOXRXUOGIU-LQDWTQKMSA-M- 분자식
- C16H17KN2O4S
- 평균 분자량
- 372.5 g/mol
- 단동위원소 질량
- 372.0546097
개요
Benzylpenicillin potassium is organic potassium salt of benzylpenicillin. It contains a benzylpenicillin(1-).
이름 및 식별자
- 우선 이름
- Penicillin G Potassium
- IUPAC
- potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
- 현지명
- 페니실린 G 칼륨
- 영어명
- Penicillin G potassium salt
- 분자식
- C16H17KN2O4S
- 분자량
- 373.49
이름 및 동의어
이름 더 보기
데이터베이스 식별자
- CAS
113-98-4- PubChem CID
- 23664709
- DTXSID
DTXSID7045106- ChEMBL
CHEMBL1223- ChEBI
CHEBI:7963- UNII
- VL775ZTH4C
- EC Number
- 204-038-0
물성
구조 계산 물성
- 극성 표면적
- 115 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 4
- 무거운 원자 수
- 24
- 형식 전하
- 0
- 복잡도
- 536
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 214 · 214-217 C
- 굴절률
- 294 ° · 294 ° (C=1, H2O)
- 저장 조건
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- 용해도
- 2 O: · H2O: 100 mg/mL
- 물리적 상태
- 가루
- 색상
- 부탄올(수용액)에서 결정화된 바늘
- 수소이온지수(pH)
- pH (10g/L, 25℃) : 5.0~7.5
- 수용성
- 물(100 mg/ml), 메탄올, 에탄올(드물게) 및 알코올에 용해됩니다. 클로로포름에 불용성.
- Merck
- 14 · 14,7094
- BRN
- 3832841 · 3832841
- 안정성
- 흡습성
- InChIKey
- IYNDLOXRXUOGIU-LQDWTQKMSA-M
- SMILES
- N12C([C@@H](NC(=O)CC3=CC=CC=C3)[C@@]1([H])SC(C)(C)[C@@H]2C([O-])=O)=O.[K+] |&1:2,13,19,r|
- EPA
- Penicillin G Potassium (113-98-4)
화학적 성질
Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase.
안전 및 규제
GHS 분류
GHS Classification
Danger
H315 (16.2%): Causes skin irritation [Warning Skin corrosion/irritation]
P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 80 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Status: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22421
Penicillin g potassium: Does not have an individual approval but may be used under an appropriate group standard
안전 데이터
- wgk
- 2
- tsca
- TSCA listed
- rtecs
- XH9700000
- 독성
- LD50 oral in rabbit: 5848mg/kg
- HS 번호
- 29411000
- risk_code
- 42/43-34-11
- hazard_code
- Xn,C,F
- safety_code
- 36/37-45-36/37/39-26-16-60-37-24-22
- 기존화학 물질
- KE-11721
- F 고인화성물질
- 10-23
- Hazard Classifications
- Skin Sens. 1
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
FDA Pharmacological Classification
BUFFERED PENICILLIN G POTASSIUM
Penicillin-class Antibacterial [EPC]; Penicillins [CS]
PENICILLIN G POTASSIUM
Penicillins [CS]; Penicillin-class Antibacterial [EPC]
용도 및 제조
응용 분야
용도Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.
일반 설명Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.
제조 방법
Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.
상·하류 제품 정보
상류 원료
하류 제품
공급사50 곳
추가 설명
정의ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).
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