페니실린 G 칼륨

Penicillin G Potassium

HCID 23664709CAS 113-98-4

기본 정보

표준 SMILES
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
InChIKey
IYNDLOXRXUOGIU-LQDWTQKMSA-M
분자식
C16H17KN2O4S
평균 분자량
372.5 g/mol
단동위원소 질량
372.0546097

개요

Benzylpenicillin potassium is organic potassium salt of benzylpenicillin. It contains a benzylpenicillin(1-).

이름 및 식별자

우선 이름
Penicillin G Potassium
IUPAC
potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
현지명
페니실린 G 칼륨
영어명
Penicillin G potassium salt
분자식
C16H17KN2O4S
분자량
373.49

이름 및 동의어

Penicillin G potassium113-98-4Benzylpenicillin potassiumPenicillin G potassium saltPotassium benzylpenicillinPotassium penicillin GPentidsBenzylpenicillin potassium saltPenicillin G KPotassium benzylpenicillinatePfizerpenbenzylpenicilline potassique
이름 더 보기
페니실린G칼륨페니실린G칼륨칼륨벤질페니실린Penicilline GPen-GPenicillin PotassiuMPenicillin G potassium First Crystalpotassium [2s-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
SugracillinCapicillinLiquapenScotcilTabilinPotassium salt of benzylpenicillinPfizerpen GPENICILLIN-2

데이터베이스 식별자

CAS
113-98-4
PubChem CID
23664709
DTXSID
DTXSID7045106
ChEMBL
CHEMBL1223
ChEBI
CHEBI:7963
UNII
VL775ZTH4C
EC Number
204-038-0

물성

구조 계산 물성

극성 표면적
115 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
5
회전 가능 결합 수
4
무거운 원자 수
24

실험 및 물리화학적 성질

Human Drugs · 2건

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Animal DrugsActive Ingredients (Penicillin G Potassium) -> FDA Greenbook
Collision Cross Section174.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

물리화학적 성질

녹는점
214 · 214-217 C
굴절률
294 ° · 294 ° (C=1, H2O)
저장 조건
-20 °C · Sealed in dry,Store in freezer, under -20°C
용해도
2 O: · H2O: 100 mg/mL
물리적 상태
가루
색상
부탄올(수용액)에서 결정화된 바늘
화학적 성질 · 1건

Penicillin G potassium salt is also known as Potassium benzylpenicillin, it is white crystalline powder, odorless or slightly specific odor, hygroscopic. Soluble in water, physiological saline, glucose solution. The aqueous solution of it is easy to fail when placed at room temperature, and it will fail rapidly in the presence of acid, alkali, oxidant, etc. Penicillin G potassium salt has good antibacterial effect on Streptococcus such as Streptococcus hemolyticus, Streptococcus pneumoniae and Staphylococcus without penicillinase.

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H315 (16.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 80 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory Information · 2건

Status: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22421

Penicillin g potassium: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2.alpha.,5.alpha.,6.beta.)]-, monopotassium salt: Environment tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (16.2%)

안전 데이터

wgk
2
tsca
TSCA listed
rtecs
XH9700000
독성
LD50 oral in rabbit: 5848mg/kg
HS 번호
29411000
risk_code
42/43-34-11

화학 및 산업

약리 정보

FDA Pharmacological Classification · 4건

BUFFERED PENICILLIN G POTASSIUM

Penicillin-class Antibacterial [EPC]; Penicillins [CS]

PENICILLIN G POTASSIUM

Penicillins [CS]; Penicillin-class Antibacterial [EPC]

MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.

용도 및 제조

Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
General Manufacturing Information4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-, potassium salt (1:1): ACTIVE
응용 분야 · 2건

용도Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. Penicillin G potassium salt is used as a cell culture additive as an antibiotics. Use to inhibit the synthesis of bacterial cell walls by inhibition of the cell wall peptidoglycan chain cross-lining. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.

일반 설명Penicillin G Potassium is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic. Penicillin G potassium binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.

제조 방법

Penicillin G potassium salt is a highly effective and low toxicity antibiotic, which is obtained by salt formation of Chlorpheniramine maleate and maleic acid.

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
清宁生物(江苏博泉生物科技有限公司)19352250998 · [email protected]

추가 설명

정의ChEBI: Penicillin G potassium salt is organic potassium salt of benzylpenicillin. It is an antibiotic substance produced by Penicillium sp. Antibacterial. It contains a benzylpenicillin(1-).

관련 반응

57건

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