6-Nitro-3-phenylacetamidobenzoic acid → 6-Aminopenicillanic acid

HRID 267183

반응식

HRID 267183 반응식
C1C=CC(CC(NC2C=CC([N+]([O-])=O)=C(C(O)=O)C=2)=O)=CC=1.[CH3:23][C:24]1([CH3:45])[S:28][C@@H:27]2[C@H:29]([NH:32]C(CC3C=CC=CC=3)=O)[C:30](=[O:31])[N:26]2[C@H:25]1[C:42]([O-:44])=[O:43].[K+]>O>[CH3:23][C:24]1([CH3:45])[S:28][C@@H:27]2[C@H:29]([NH2:32])[C:30](=[O:31])[N:26]2[C@H:25]1[C:42]([OH:44])=[O:43]

참가 물질

4

반응물 2

HCID 1938646-Nitro-3-phenylacetamidobenzoic acidHCID 23664709Penicillin G Potassium

생성물 1

HCID 110826-Aminopenicillanic acid

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
38 °C

실험 절차

120 g of carrier-bound penicillinacylase (moist weight) according to Example 4, with an activity of 1,160 U (NIPAB test) and 120 g of potassium penicillin G, are introduced into 1,300 ml of water and stirred for 9 hours at 38°C. and pH 7.8, as described in Example 14. The mixture is worked up as described in Example 14. The carrier-bound penicillinacylase is employed 5 times in succession for the enzymatic splitting reaction. The yields of 6-APS achieved are listed below:

후처리

  1. customfor the enzymatic splitting reaction

출처 및 근거

ORD 기록
ord-741bdb9948c84a0cb32c17c4d75c97b1
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03941756

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