Sodium Hydroxide → N-Acetyl-L-phenylalanine

HRID 267311

반응식

HRID 267311 반응식
[OH-].[Na+].[C:3]([NH:6][C@H:7]([C:15]([OH:17])=[O:16])[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:5])[CH3:4].Cl.[CH3:19][O:20][C:21](=[O:31])[CH:22]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[NH2:23]>>[C:3]([NH:6][C@H:7]([C:15]([OH:17])=[O:16])[CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)(=[O:5])[CH3:4].[CH3:19][O:20][C:21](=[O:31])[C@@H:22]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[NH2:23]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 74839N-Acetyl-L-phenylalanineHCID 3084017Methyl 3-phenyl-DL-alaninate hydrochloride

생성물 2

HCID 74839N-Acetyl-L-phenylalanineHCID 853474(R)-Methyl 2-amino-3-phenylpropanoate

실험 절차

To 310 parts by volume of an aqueous 0.5N sodium hydroxide solution, heated to about 70°, is added, successively, 17.7 parts of N-acetyl-L-phenylalanine and 33.3 parts of DL-phenylalanine methyl ester hydrochloride. A precipitate forms and upon cooling and filtering, the salt of N-acetyl-L-phenylalanine and D-phenylalanine methyl ester is obtained. Recrystallization from hot water affords the pure salt exhibiting an [α]D in 0.5% water of about +32.2°.

후처리

  1. additionis added
  2. temperatureA precipitate forms and upon cooling
  3. filtrationfiltering

출처 및 근거

ORD 기록
ord-39fe7e25f49b420b9fc236a8b4116a5c
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03941831

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