Ethanol → HCID 178479532, 화합물

HRID 267324

반응식

HRID 267324 반응식
Cl.[NH2:2][NH:3][C:4]([NH:6][NH2:7])=[NH:5].C(O)C.[Cl:11][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=O)=[CH:14][CH:13]=1.[OH-].[Na+]>O>[ClH:11].[NH2:2][NH:3][C:4]([NH:6][N:7]=[CH:16][C:15]1[CH:18]=[CH:19][C:12]([Cl:11])=[CH:13][CH:14]=1)=[NH:5]

참가 물질

6

반응물 4

HCID 702Ethanol2회HCID 77264-ChlorobenzaldehydeHCID 14798Sodium HydroxideHCID 178479531HCID 178479531, 화합물

생성물 1

HCID 178479532HCID 178479532, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
0 °C

실험 절차

The preparation of the subject compound may also be accomplished as follows: 25 g. of 1,3-diaminoguanidine hydrochloride is dissolved in 1800 ml. of boiling ethanol. To this boiling solution, 28 g. of 4-chlorobenzaldehyde in 300 ml. of ethanol is added over a period of 8 hours. The reaction mixture is then cooled at 0°C. overnight, clarified, and the filtrate concentrated to 500 ml. volume and cooled at 0°C. 29 g. of precipitate is obtained. This is slurried in 300 ml. of water, the pH adjusted to 8-8.5 with sodium hydroxide solution, the slurry heated to boiling and filtered. Cooling and filtrate gives 18 g. of essentially pure product melting at 243°-244°C., as in the previous preparation.

후처리

  1. customThe preparation of the subject compound
  2. concentrationthe filtrate concentrated to 500 ml
  3. temperaturevolume and cooled at 0°C
  4. customof precipitate is obtained
  5. temperaturethe slurry heated
  6. filtrationfiltered
  7. temperatureCooling
  8. customfiltrate gives 18 g

출처 및 근거

ORD 기록
ord-16970a2d491149708bb78afe75a5f287
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03941825

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