2-Indanone → 2-Indanol

HRID 267560

반응식

HRID 267560 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[BH4-].[Na+]>CO>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[OH:10]

참가 물질

4

반응물 2

HCID 119832-IndanoneHCID 4311764Sodium borohydride

생성물 1

HCID 779362-Indanol수율 96.6%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

A 60 g sample of 2-indanone (0.45 moles) in 1.5 liters of 40% aqueous methanol was treated with 18 g (0.46 moles) of sodium borohydride in portions with cooling to maintain T≤ 40°C. After the addition was complete (15 min), the mixture was stirred for 2 hrs then allowed to stand overnight at room temp. Ether extraction, drying over potassium carbonate and evaporation gave 58.3 g crystalline 2-indanol (96%).

후처리

  1. temperaturewith cooling
  2. additionAfter the addition
  3. custom(15 min)
  4. waitto stand overnight at room temp
  5. extractionEther extraction
  6. dry with materialdrying over potassium carbonate and evaporation

출처 및 근거

ORD 기록
ord-6c8acacc781249eebb82cb28dffc8a49
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03943149

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