Ethyl chloroformate → HCID 21553694, 화합물

HRID 267676

반응식

HRID 267676 반응식
[F:1][C:2]([F:15])([F:14])[NH:3][C:4]([N:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[OH:7])=[O:5].[OH-].[Na+].Cl[C:19](OCC)=[O:20]>>[C:8]1([N:6]2[C:4](=[O:5])[N:3]([C:2]([F:14])([F:15])[F:1])[C:19](=[O:20])[O:7]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 215536781-Trifluoromethyl-3-phenyl-3-hydroxyurea

생성물 1

HCID 21553694HCID 21553694, 화합물

실험 절차

1-Trifluoromethyl-3-phenyl-3-hydroxyurea (11 grams; 0.05 mol) is dissolved in a cooled (10°C) 2N aqueous sodium hydroxide solution (35 ml). Ethyl chloroformate (6 ml; 0.06 mol) is added dropwise at 10° to 15°C with stirring. Stirring is continued for a period of about 1/2 hour after the addition is completed resulting in the formation of a precipitate. The precipitate is recovered by filtration, washed with water and dried to yield 2-phenyl-4-trifluoromethyl-1,2,4-oxadiazolidine-3,5-dione.

후처리

  1. stirringStirring
  2. additionafter the addition
  3. customis completed resulting in the formation of a precipitate
  4. filtrationThe precipitate is recovered by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-8c6a015cad7a4a71ab11bce0ca7d41a5
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03944410

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