Hydrochloric Acid → 3-(Benzyloxy)benzene-1,2-diol
반응식
COC1(C)[O:7][C:6]2[CH:8]=[CH:9][CH:10]=[C:11]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:5]=2[O:4]1.Cl>CO>[CH2:13]([O:12][C:11]1[CH:10]=[CH:9][CH:8]=[C:6]([OH:7])[C:5]=1[OH:4])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1참가 물질
4
실험 절차
A mixture of 2-methoxy-2-methyl-4-benzyloxy-1,3-benzodioxole (13.6 g., 0.05 mole), methanol (210 ml.) and 5N hydrochloric acid (210 ml.) is stirred under reflux in an atmosphere of nitrogen for 10 hours. Most of the methanol is distilled off under vacuum and the product then extracted with ether. The ethereal solution is washed with water, dried over magnesium sulfate followed by calcium sulfate and evaporated to dryness to yield the crude 3-benzyloxy-catechol which can be recrystallized from di-isopropyl ether.
후처리
- temperatureunder reflux in an atmosphere of nitrogen for 10 hours
- distillationMost of the methanol is distilled off under vacuum
- extractionthe product then extracted with ether
- washThe ethereal solution is washed with water
- dry with materialdried over magnesium sulfate
- customevaporated to dryness
출처 및 근거
- ORD 기록
- ord-cf8fe09b4d854d44912f7654216a4cc3
- 출처 데이터셋
- uspto-grants-1976_03
- 특허 번호
- US03944560
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