O-Xylene → 5-Fluoro-2-methylindan-1-one

HRID 267822

반응식

HRID 267822 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:13])[CH:9]([CH3:12])[CH2:10]O)=[CH:4][CH:3]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O.C1(C)C(C)=CC=CC=1>O>[F:1][C:2]1[CH:7]=[C:6]2[C:5](=[CH:4][CH:3]=1)[C:8](=[O:13])[CH:9]([CH3:12])[CH2:10]2

참가 물질

5

반응물 3

HCID 7237O-XyleneHCID 14812Phosphorus oxide (P4O10)HCID 215218911-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one

생성물 1

HCID 30162575-Fluoro-2-methylindan-1-one

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for one hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.

후처리

  1. additionA mixture of 18.2 g
  2. temperatureThe reaction is cooled
  3. washthe xylene layer is washed with aqueous sodium hydroxide and water
  4. concentrationThe organic layer is then concentrated in vacuo

출처 및 근거

ORD 기록
ord-e35a1b1b9bd74744aba18c195be0050a
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03944600

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