Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-Xylene → 5-Fluoro-2-methylindan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-Xylene | HCID 7237 | — |
| 반응물 | Phosphorus oxide (P4O10) | HCID 14812 | — |
| 반응물 | 1-(4-Fluorophenyl)-3-hydroxy-2-methylpropan-1-one | HCID 21521891 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Fluoro-2-methylindan-1-one | HCID 3016257 | — |
반응 단계
A mixture of 18.2 g. (0.10 mole) of 4'-fluoro-3-hydroxy-2-methylpropiophenone and 12 g. of phosphorous pentoxide in 100 ml. of xylene is refluxed for one hour. The reaction is cooled, water is added and the xylene layer is washed with aqueous sodium hydroxide and water. The organic layer is then concentrated in vacuo to give 5-fluoro-2-methyl-1-indanone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03944600 |
| 출처 데이터셋 | uspto-grants-1976_03 |
| ORD ID | ord-e35a1b1b9bd74744aba18c195be0050a |
| 출처 메모 | uspto-grants-1976_03 |