Phosphorus oxychloride → 2-Methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-YL)-2-pyrrolin-2-YL]phenothiazine hydrochloride

HRID 267916

반응식

HRID 267916 반응식
[CH3:1][CH:2]1[NH:6][C:5](=O)[CH2:4][CH2:3]1.[CH3:8][O:9][C:10]1[CH:23]=[CH:22][C:21]2[S:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[NH:13][C:12]=2[CH:11]=1.P(Cl)(Cl)([Cl:26])=O>ClCCCl>[ClH:26].[CH3:8][O:9][C:10]1[CH:23]=[CH:22][C:21]2[S:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]([C:5]3[N:6]([C:5]4[CH2:4][CH2:3][CH:2]([CH3:1])[N:6]=4)[CH:2]([CH3:1])[CH2:3][CH:4]=3)[C:12]=2[CH:11]=1

참가 물질

5

반응물 3

HCID 24813Phosphorus oxychlorideHCID 660555-Methyl-2-pyrrolidoneHCID 74490Methyl phenothiazin-2-yl ether

생성물 1

HCID 203071352-Methoxy-10-[5-methyl-1-(5-methyl-1-pyrrolin-2-YL)-2-pyrrolin-2-YL]phenothiazine hydrochloride수율 8.6%

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

Reaction of 5-methyl-2-pyrrolidinone, 2-methoxyphenothiazine and phosphorus oxychloride in 1,2-dichloroethane according to the procedure of Example 4 affords 2-METHOXY-10-[5-METHYL-1-(5-METHYL-1-PYRROLIN-2-YL)-2-PYRROLIN-2-YL]PHENOTHIAZINE HYDROCHLORIDE (8.6% yield), m.p. 236.5°-238.5° C. (corr.), from ethanol-ether.

출처 및 근거

ORD 기록
ord-e2b9cc5433e04e85a624d578ad21690a
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03946004

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