Sodium Hydroxide → 7H-indolizino[5,6,7-ij]isoquinolin-7-one
반응식
ON=[C:3]1[C:17]2[C:18]3[C:13]([CH:14]=[CH:15][N:16]=2)=[CH:12][CH:11]=[CH:10][C:9]=3[N:8]2[C:4]1=[CH:5][CH:6]=[CH:7]2.[OH-:19].[Na+]>C(O)C.O>[CH:10]1[C:9]2[N:8]3[C:4]([C:3](=[O:19])[C:17]4[C:18]=2[C:13]([CH:14]=[CH:15][N:16]=4)=[CH:12][CH:11]=1)=[CH:5][CH:6]=[CH:7]3참가 물질
5
실험 절차
The 7-Imino-7H-indolizino[5,6,7-ij]isoquinoline (110 g.) and N sodium hydroxide solution ( ##SPC14## cc.) in ethanol (4.4 liters) and water (4.4 liters) are heated under reflux for 4 hours. After cooling, 7H-indolizino[5,6,7-ij]isoquinolin-7-one (108.1 g.) is obtained in the form of yellow needles melting at 264° C.
후처리
- temperatureunder reflux for 4 hours
- temperatureAfter cooling
출처 및 근거
- ORD 기록
- ord-af67098dedfa47c39e05fd40943f9d1d
- 출처 데이터셋
- uspto-grants-1976_03
- 특허 번호
- US03946019
반응 노트
불러오는 중…