Sodium borohydride → HCID 21553303, 화합물

HRID 268093노트

반응식

HRID 268093 반응식
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:14][C:13]([C:15]#[N:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[BH4-].[Na+]>O1CCOCC1.O>[OH:3][CH:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[O:14][C:13]([C:15]#[N:16])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1)[CH3:2]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 215533215-(4-Acetylphenyl)furan-2-carbonitrile

생성물 1

HCID 21553303HCID 21553303, 화합물수율 58%

시약·촉매·용매 1

HCID 218864351,4-Dioxane--water (1/1)용매

실험 절차

A solution of 46 g (0.22 mole) of 5-(4-acetylphenyl)-2-furonitrile in 800 ml of 95% dioxane/H2O was treated portionwise with 8.3 g (0.22 mole) of NaBH4 while keeping the temperature below 20° by means of an ice bath. The resulting solution was stirred at ambient temperature for 21/2 hours and then added to an ice/H2O mixture. After standing 48 hours, the reaction mixture was extracted with ether and the combined ethereal extracts dried over MgSO4. The ether was removed on the Calab evaporator yielding 27 g (58%) of product as a residual oil.

후처리

  1. customthe temperature below 20°
  2. waitAfter standing 48 hours
  3. extractionthe reaction mixture was extracted with ether
  4. dry with materialthe combined ethereal extracts dried over MgSO4
  5. customThe ether was removed on the Calab evaporator

출처 및 근거

ORD 기록
ord-1e4ddf3d09834c9ba1ffe986b44a8551
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03946049

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