Chloroform → 5-Formyl-2-thiophenecarboxylic Acid

HRID 268147

반응식

HRID 268147 반응식
[CH3:1][C:2]1[S:3][C:4]([C:7]([OH:9])=[O:8])=[CH:5][CH:6]=1.C(Cl)(Cl)Cl.BrBr.C(=O)([O-])[O-:17].[Na+].[Na+]>C(Cl)(Cl)(Cl)Cl.[W]>[CH:1]([C:2]1[S:3][C:4]([C:7]([OH:9])=[O:8])=[CH:5][CH:6]=1)=[O:17]

참가 물질

7

반응물 4

HCID 6212ChloroformHCID 10340Sodium CarbonateHCID 24408Bromine2회HCID 747135-Methylthiophene-2-carboxylic acid

생성물 1

HCID 8188825-Formyl-2-thiophenecarboxylic Acid

시약·촉매·용매 2

HCID 23964Tungsten촉매HCID 5943Carbon Tetrachloride용매2회

실험 절차

2-Methyl thiophen-5-carboxylic acid was dissolved in carbon tetrachloride (150 ml.) and chloroform (10 ml.) and AZDN (0.5g.) was added. The mixture was refluxed over a 150 watt tungsten spotlight. Two molar equivalents of bromine as a 30% v/v solution in carbon tetrachloride were slowly added. A precipitate was formed but the mixture continued to take up bromine. After the addition of the two molar equivalents, solvent was boiled off until the volume was 100 ml. and the product treated with sodium carbonate solution with gentle heating for two hours to obtain 2-formyl thiophen-5-carboxylic acid in the form of a yellow solid after acidification, extraction and removal of the solvent.

후처리

  1. customA precipitate was formed
  2. additionAfter the addition of the two molar equivalents, solvent
  3. temperaturewith gentle heating for two hours

출처 및 근거

ORD 기록
ord-b6867c0130184750802e3e579b65ce10
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947336

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