Borane → 1,2,3,5,10,11a-Hexahydro-10-methyl-11H-pyrrolo[2,1-c] [1,4] benzodiazepin-11-one

HRID 268164

반응식

HRID 268164 반응식
[CH3:1][N:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C:6](=O)[N:5]2[CH2:14][CH2:15][CH2:16][CH:4]2[C:3]1=[O:17].CN1C(=O)OC(=O)C2=CC=CC=C12.N1CCC[C@@H]1C(O)=O.B>O1CCCC1.CO>[CH3:1][N:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][N:5]2[CH2:14][CH2:15][CH2:16][CH:4]2[C:3]1=[O:17]

참가 물질

7

반응물 4

HCID 6331BoraneHCID 8988D-ProlineHCID 25160N-Methylisatoic anhydrideHCID 985943610-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione

생성물 1

HCID 545015291,2,3,5,10,11a-Hexahydro-10-methyl-11H-pyrrolo[2,1-c] [1,4] benzodiazepin-11-one

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

The above compound is obtained when (-)-1,2,3,11 a-tetrahydro-10-methyl-5H-pyrrolo[2,1-c] [1,4] benzodiazepin- 5,11(10H)-dione, melting point 120-122°C. [α]D 25 - 477°, (1.24%, methanol) and (prepared from N-methylisatoic anhydride and D-proline as described in Example 1) is treated with borane in tetrahydrofuran as described in Example 1.

후처리

  1. customThe above compound is obtained

출처 및 근거

ORD 기록
ord-ad14593739a846938701f4f516ce75c5
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947408

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