Formaldehyde → (3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

HRID 268240

반응식

HRID 268240 반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[CH2:11]=O.[CH:13]1[CH:14]=[C:15]2[C:20]3=[C:21]([C:23]([NH:25][C:26](=[O:27])[C:19]3=[CH:18][CH:17]=[CH:16]2)=[O:24])[CH:22]=1>CN(C)C=O>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][N:25]1[C:26](=[O:27])[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]3[C:20]=2[C:21](=[CH:22][CH:13]=[CH:14]3)[C:23]1=[O:24]

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 70461,2,3,4-TetrahydroisoquinolineHCID 66491Naphthalimide

생성물 1

HCID 21551797(3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

An equimolar mixture of 1,2,3,4-tetrahydroisoquinoline, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield 2-[(3,4-dihydro-2(1H)-isoquinolinylmethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione.

후처리

  1. temperaturethe mixture is heated until dissolution
  2. customto stand at room temperature
  3. filtrationthe resulting precipitate is filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-86ae842f9f6b4d99be980a88a6d2904a
출처 데이터셋
uspto-grants-1976_03
특허 번호
US03947452

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